AI for Complex Systems
Machine learning and data science methods for modeling, prediction, optimization, and decision support in complex systems.
Data Science for Intelligent Systems Laboratory
We develop next-generation data science and artificial intelligence methods for modeling, understanding, and optimizing complex systems across healthcare, manufacturing, transportation, and smart infrastructure.
Research Vision
The DSIS Laboratory bridges methodological innovation with real-world decision making by developing scalable, interpretable, and trustworthy AI algorithms that transform high-dimensional and multimodal data into actionable insights.
Welcome
Welcome to the DSIS Laboratory
The Data Science for Intelligent Systems Laboratory is led by Dr. Meng Zhao in the Department of Industrial & Systems Engineering at Lehigh University.
Our research lies at the intersection of Industrial & Systems Engineering, Machine Learning, Operations Research, and AI. We design methods that support intelligent system modeling, prediction, optimization, and decision support.
Research
Core Research Themes
We develop AI and data science methods that turn heterogeneous, high-dimensional, and multimodal data into knowledge for complex engineering and societal systems.
High-Dimensional Data Analytics
Scalable statistical learning for tensors, graphs, structured data, and multimodal datasets.
Tensor & Multimodal Learning
Tensor decomposition and tensor learning algorithms that preserve higher-order structure for downstream machine learning.
AI for Healthcare
Trustworthy AI for computational phenotyping, disease subtyping, clinical risk prediction, precision medicine, and treatment recommendation.
Smart Operations & Infrastructure
AI-enabled learning and optimization for manufacturing, scheduling, predictive maintenance, transportation, and urban systems.
Responsible & Trustworthy AI
Explainable AI, robustness, uncertainty quantification, privacy-preserving learning, federated learning, and human-centered AI.
People
Group members and collaborators
The DSIS Laboratory brings together researchers interested in AI, machine learning, data science, optimization, tensor learning, healthcare analytics, and intelligent systems.
We actively collaborate across Industrial & Systems Engineering, Computer Science, Biomedical Informatics, Statistics, Medicine, and Public Health.
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Meng Zhao, Ph.D.
Principal Investigator
Jiawei Guo
Postdoctoral Researcher
Publications
Selected Publications
FedPAR: Federated PARAFAC2 Tensor Factorization for Computational Phenotyping
IISE Transactions on Healthcare Systems Engineering, 2024.
Robust Coupled Tensor Decomposition and Feature Extraction for Multimodal Medical Data
IISE Transactions on Healthcare Systems Engineering, 2023.
Identification of Transcriptomic Sepsis Endotypes in Sub-Saharan Africa
Collaborative work integrating AI and genomics for precision medicine.
News
Latest News
🎉 Dr. Zhao elected IISE DAIS Division Director
Dr. Meng Zhao was elected Director of the Data Analytics and Information Systems Division of IISE for the 2026–2028 term.
🎓 AI Course Transformation Grant
Dr. Zhao received Lehigh University's AI Course Transformation Grant to develop innovative AI education and curriculum initiatives.
💰 PITA Research Grant
Dr. Zhao received a Pennsylvania Infrastructure Technology Alliance grant for a Jefferson Health collaboration using large language models to predict hospital readmissions from free-text clinical notes.